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Endocrine Abstracts

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ea0092op-07-02 | Oral Session 7: Thyroid hormone receptors | ETA2023

Tanycytic thyroid hormone signalling in the regulation of hypothalamic functions and hormone uptake

Chandrasekar Akila , Abele Sebastian , Fahnrich Anke , Spiecker Frauke , Mittag Jens , Schwaninger Markus , Muller-Fielitz Helge

Thyroid hormones (TH) play an important role in brain development, central nervous system functions and energy metabolism. In order to mediate these effects in the brain, TH are actively transported through the blood-brain barrier from the periphery to the brain. Tanycytes are specialized ependymal cells that line the wall and the base of the third ventricle in the mediobasal hypothalamus. The cell bodies are in contact with the cerebrospinal fluid and send their processes to ...
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ea0094p371 | Neuroendocrinology and Pituitary | SFEBES2023

GnRH neuronal disruption and hypotestosteronemia in COVID-19

Sauve Florent , Nampoothiri Sreekala , Clarke Sophie , Fernandois Daniela , Fernando Ferreira Coelho Caio , Dewisme Julie , G Mills Edouard , Ternier Gaetan , Cotellessa Ludovica , Iglesias Garcia Cristina , Mueller-Fielitz Helge , Lebouvier Thibaud , Perbet Romain , Florent Vincent , Baroncini Marc , Sharif Ariane , Ereno-Orbea June , Mercado-Gomez Maria , Palazon Asis , Mattot Virginie , Pasquier Florence , Catteau-Jonard Sophie , Martinez-Chantar Maria , Hrabovszky Erik , Jourdain Merce , Deplanque Dominique , Morelli Annamaria , Guarnier Giulia , Storme Laurent , Robil Cyril , Trottein Francois , Nogueiras Ruben , Schwaninger Markus , Pigny Pascal , Poissy Julien , Chachlaki Konstantina , Maurage Claude-Alain , Giacobini Paolo , S Dhillo Waljit , Rasika S , Prevot Vincent

Loss of gonadotropin-releasing hormone (GnRH) and cognitive deficits have recently been demonstrated by our group in conditions including Down syndrome and Alzhiemer’s disease. In some patients with COVID-19, olfactory and cognitive alterations persist, and persistent hypotestosteronemia in SARS-CoV-2-infected men could be a consequence of deficient GnRH. To understand whether neuroinvasion of GnRH system by SARS-CoV-2 could explain some post-COVID symptoms and thus resul...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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